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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM3
All Species:
33.64
Human Site:
Y45
Identified Species:
52.86
UniProt:
P25205
Number Species:
14
Phosphosite Substitution
Charge Score:
0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P25205
NP_002379.2
808
90981
Y45
E
L
I
S
D
N
Q
Y
R
L
I
V
N
V
N
Chimpanzee
Pan troglodytes
XP_001151750
808
90957
Y45
E
L
I
S
D
N
Q
Y
R
L
I
V
N
V
N
Rhesus Macaque
Macaca mulatta
XP_001106966
808
90990
Y45
E
L
I
S
D
N
Q
Y
R
L
I
V
N
V
N
Dog
Lupus familis
XP_538960
916
102667
Y153
E
L
I
S
D
N
Q
Y
R
L
I
V
N
V
N
Cat
Felis silvestris
Mouse
Mus musculus
P25206
812
91528
Y45
E
L
I
S
D
N
Q
Y
R
L
I
V
S
V
N
Rat
Rattus norvegicus
XP_001070728
813
91641
Y45
E
L
I
S
D
N
Q
Y
R
L
I
V
N
V
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZMN2
812
91233
Y46
D
M
I
S
D
N
Q
Y
R
L
L
V
N
I
N
Frog
Xenopus laevis
Q7ZXZ0
806
90528
Y45
D
M
I
S
E
N
Q
Y
R
L
I
V
N
I
N
Zebra Danio
Brachydanio rerio
NP_997732
807
90502
E70
K
L
L
N
N
A
F
E
E
L
L
A
F
Q
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_511048
819
90900
I45
A
E
K
S
K
R
L
I
V
N
V
N
D
L
K
Honey Bee
Apis mellifera
XP_625020
811
91329
Y46
E
E
G
N
R
R
L
Y
I
N
V
N
D
L
R
Nematode Worm
Caenorhab. elegans
Q21902
759
84917
G50
I
R
D
F
S
T
G
G
F
G
M
I
Y
R
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q43704
768
85163
D49
R
L
I
I
G
M
D
D
L
R
N
H
N
L
D
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FL33
776
86338
E62
R
I
L
K
N
P
N
E
Y
M
Q
S
F
C
D
Baker's Yeast
Sacchar. cerevisiae
P24279
971
107499
H94
T
S
L
N
I
L
P
H
R
I
I
I
S
L
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99.5
86
N.A.
92.9
93.3
N.A.
N.A.
81.4
80.1
75.9
N.A.
62.5
62.7
30.8
N.A.
Protein Similarity:
100
99.8
100
87.2
N.A.
96.6
97
N.A.
N.A.
92
90.7
88.1
N.A.
80
78.6
49.5
N.A.
P-Site Identity:
100
100
100
100
N.A.
93.3
100
N.A.
N.A.
73.3
73.3
13.3
N.A.
6.6
13.3
0
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
100
46.6
N.A.
26.6
40
20
N.A.
Percent
Protein Identity:
N.A.
47.6
N.A.
49.3
39.8
N.A.
Protein Similarity:
N.A.
66
N.A.
68.1
54.7
N.A.
P-Site Identity:
N.A.
20
N.A.
0
13.3
N.A.
P-Site Similarity:
N.A.
33.3
N.A.
33.3
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
0
7
0
0
0
0
0
7
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% C
% Asp:
14
0
7
0
47
0
7
7
0
0
0
0
14
0
27
% D
% Glu:
47
14
0
0
7
0
0
14
7
0
0
0
0
0
0
% E
% Phe:
0
0
0
7
0
0
7
0
7
0
0
0
14
0
0
% F
% Gly:
0
0
7
0
7
0
7
7
0
7
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
7
0
0
0
7
0
0
0
% H
% Ile:
7
7
60
7
7
0
0
7
7
7
54
14
0
14
0
% I
% Lys:
7
0
7
7
7
0
0
0
0
0
0
0
0
0
7
% K
% Leu:
0
54
20
0
0
7
14
0
7
60
14
0
0
27
0
% L
% Met:
0
14
0
0
0
7
0
0
0
7
7
0
0
0
0
% M
% Asn:
0
0
0
20
14
54
7
0
0
14
7
14
54
0
54
% N
% Pro:
0
0
0
0
0
7
7
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
54
0
0
0
7
0
0
7
0
% Q
% Arg:
14
7
0
0
7
14
0
0
60
7
0
0
0
7
14
% R
% Ser:
0
7
0
60
7
0
0
0
0
0
0
7
14
0
0
% S
% Thr:
7
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
7
0
14
54
0
40
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
60
7
0
0
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _